A fountain of youth for stem cells
نویسندگان
چکیده
منابع مشابه
Stem cells: the chameleon fountain of youth.
Senescence requires rejuvenation of organs critical to survival. To date, efforts at “rejuvenation” of the heart have largely used replacement (orthotopic transplantation) and, more recently, mechanical biventricular assist devices. These strategies have been hampered by the limited availability of donor organs and the high levels of immunosuppression required to prevent transplanted organ reje...
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Embryonic stem cells readily generate neurons in vitro, but steering their differentiation into specific neuronal subtypes is a major challenge. It has now been shown that mechanisms that regulate neuronal specification during development can be applied to embryonic stem cells in vitro; this may lead to new ways of generating cells for therapy.
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Transfusion (or drinking) of blood or of its components has been thought as a rejuvenation method since ancient times. Parabiosis, the procedure of joining two animals so that they share each others blood circulation, has revitalized the concept of blood as a putative drug. Since 2005, a number of papers have reported the anti-ageing effect of heterochronic parabiosis, which is joining an aged ...
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Just a few years ago, the rules of blood vessel formation seemed simple. Endothelial cells emerged from the blood islands of the embryo to form primitive tubes, the precursors of the vasculature. Smooth muscle cells, recruited locally from various germ layers, invested the endothelial tubes, forming the sandwich structure of mature arteries and veins. Mechanical or metabolic injury supposedly s...
متن کاملTAp63: The fountain of youth
The mechanisms controlling organismal aging have yet to be clearly defined. In our recent paper [1], we revealed thatTAp63, the p53 family member, is a critical gene in preventing organismal aging by controlling the maintenance of dermal and epidermal precursor and stem cells critical for wound healing and hair growth. In the absence of TAp63, dermal stem cells (skin-derived precursors or SKPs)...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2014
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2990